Democrat Annie Andrews, a pediatrician, defeated Senator Darline Graham and became the first Democrat elected to the U.S.

Senate in South Carolina in 28 years and the first woman elected to represent the state in the chamber. Before her, Fritz Hollings was the last Democrat elected to a Senate seat in South Carolina, winning his final term in 1998. Graham had held the seat since July, appointed after the sudden death of her brother, Senator Lindsey Graham, a move that won support from President Donald Trump. Trump won the state by 18 points in 2024.